Watkins J S, Campbell M J, Gardner-Medwin D, Ingham H R, Murray I G
Br Med J. 1969 Jul 5;3(5661):29-31. doi: 10.1136/bmj.3.5661.29.
Cryptococcal meningitis occurred in two patients in the North of England. One, an elderly woman who was ill for 12 months with an obscure indolent meningitis until use of steroid drugs resulted in an acute exacerbation during which cryptococci were isolated, was treated successfully with amphotericin B. The other, a student from New Guinea with subacute meningitis, could not tolerate amphotericin B but responded to two courses of oral treatment with 5-fluorocytosine 100-200 mg./kg./ day without any appreciable side-effects. Further trials of this drug in the treatment of cryptococcosis are recommended.
英格兰北部有两名患者发生了隐球菌性脑膜炎。其中一名是老年女性，患隐匿性慢性脑膜炎12个月，使用类固醇药物后病情急性加重，期间分离出隐球菌，用两性霉素B成功治愈。另一名是来自新几内亚的学生，患亚急性脑膜炎，无法耐受两性霉素B，但对每天100 - 200毫克/千克的5-氟胞嘧啶口服治疗两个疗程有反应，且无明显副作用。建议对该药治疗隐球菌病进行进一步试验。
