Pyke D A, Cassar J, Todd J, Taylor K W
Br Med J. 1970 Dec 12;4(5736):649-51. doi: 10.1136/bmj.4.5736.649.
Glucose tolerance with serum insulin assay has been carried out in 24 apparently unaffected identical twins of diabetics. Glucose values were significantly higher and insulin values significantly lower than in control subjects, but there was considerable individual variation and in half the cases glucose tolerance was normal. There was no case of increased insulin response. In these twins glucose tolerance and insulin response were not correlated with weight, family history of diabetes, age at diagnosis of diabetes in the affected twin, time since that diagnosis, nor with age at testing the unaffected twin. On retesting 12 of the twins after two years no significant differences were found from the first testing.We conclude that not all these twins are likely to develop diabetes, that the assumption that identical twins of diabetics are necessarily "prediabetic" is probably erroneous, and that factors other than genetic ones are important in the aetiology of diabetes.
对24对表面上未受影响的糖尿病同卵双胞胎进行了葡萄糖耐量及血清胰岛素检测。与对照受试者相比，这些双胞胎的血糖值显著更高，胰岛素值显著更低，但个体差异很大，半数情况下葡萄糖耐量正常。没有胰岛素反应增加的病例。在这些双胞胎中，葡萄糖耐量和胰岛素反应与体重、糖尿病家族史、患病双胞胎糖尿病诊断时的年龄、自诊断以来的时间以及未患病双胞胎检测时的年龄均无相关性。两年后对其中12对双胞胎进行重新检测，结果与首次检测无显著差异。我们得出结论，并非所有这些双胞胎都可能患糖尿病，认为糖尿病患者的同卵双胞胎必然“处于糖尿病前期”的假设可能是错误的，而且除遗传因素外，其他因素在糖尿病病因学中也很重要。
