影响感染脑心肌炎病毒的小鼠中类似糖尿病疾病发生的遗传因素。
Genetic influences affecting the occurrence of a diabetes mellitus-like disease in mice infected with the encephalomyocarditis virus.
作者信息
Craighead J E, Higgins D A
出版信息
J Exp Med. 1974 Feb 1;139(2):414-26. doi: 10.1084/jem.139.2.414.
Abstract
The M variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in DBA/2 mice but not in animals of the C3H strain. Fewer than one-third of infected F(1) (DBA/2 x C3H) progeny exhibit the disease, whereas the prevalence in backcrosses (F(1) x DBA/2, F(1) x C3H) is comparable to the parental inbred strain. Thus, the mode of inheritance of the diabetic predisposition appears to be polygenic. DBA/2 animals develop striking inflammatory and necrotizing lesions of the islets of Langerhans; in contrast, alterations of the insular tissue in the C3H mice are minimal. Although metabolic abnormalities appear to be consequent to lesions of beta cells, the factors influencing the severity of these insular changes are incompletely understood.
摘要
脑心肌炎病毒的M变体在DBA/2小鼠中会引发类似糖尿病的疾病，但在C3H品系的动物中则不会。感染的F(1)（DBA/2×C3H）子代中不到三分之一会出现这种疾病，而回交（F(1)×DBA/2，F(1)×C3H）中的患病率与亲代近交系相当。因此，糖尿病易感性的遗传模式似乎是多基因的。DBA/2动物的胰岛会出现明显的炎症和坏死性病变；相比之下，C3H小鼠的胰岛组织变化极小。尽管代谢异常似乎是β细胞损伤的结果，但影响这些胰岛变化严重程度的因素尚未完全了解。
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