大鼠心脏和肝脏线粒体中的血红素a、细胞色素c与总蛋白周转
Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver.
作者信息
Aschenbrenner B, Druyan R, Albin R, Rabinowitz M
出版信息
Biochem J. 1970 Sep;119(2):157-60. doi: 10.1042/bj1190157.
Abstract
Haem a and cytochrome c were isotopically labelled in mitochondria from rat heart and liver after injection of delta-amino[2,3-(3)H(2)]laevulate, a specific haem precursor. [guanido-(14)C]Arginine or l-[4,5-(3)H(2)]leucine were used to label mitochondrial proteins. Half-lives were measured from biological decay in vivo and were similar (5.5-6.2 days) for haem a, cytochrome c and [(14)C]arginine-labelled proteins. Labelling of hepatic mitochondrial proteins with [(3)H(2)]leucine resulted in a prolonged apparent half-life.
摘要
在注射特异性血红素前体δ-氨基[2,3-(3)H(2)]戊酸后，大鼠心脏和肝脏线粒体中的血红素a和细胞色素c被同位素标记。[胍基-(14)C]精氨酸或L-[4,5-(3)H(2)]亮氨酸用于标记线粒体蛋白质。通过体内生物衰变测量半衰期，血红素a、细胞色素c和[(14)C]精氨酸标记的蛋白质的半衰期相似(5.5 - 6.2天)。用[(3)H(2)]亮氨酸标记肝线粒体蛋白质导致明显延长的半衰期。
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