Ramsay A M, Rundle A
Postgrad Med J. 1979 Dec;55(654):856-7. doi: 10.1136/pgmj.55.650.856.
Ten patients in whom the clinical findings were consistent with the syndrome variously described as 'benign myalgic encephalomyelitis', 'epidemic neuromyasthenia', 'Royal Free disease' and 'Icelandic disease' were investigated for blood levels of myoglobin and various enzymes. Although there is no clinical resemblance between the two diseases, the biochemical pattern bears a close similarity to that found in Duchenne muscular dystrophy (DMD) though differing sharply in that no rise in creatinine kinase levels was found. These findings are discussed with particular reference to recent suggestions that the permeability of cell membranes may be impaired by changes in intracellular energy mechanisms.
对10名临床症状与被不同描述为“良性肌痛性脑脊髓炎”“流行性神经肌无力”“皇家自由病”和“冰岛病”综合征相符的患者进行了肌红蛋白和各种酶的血液水平检测。尽管这两种疾病在临床症状上没有相似之处，但生化模式与杜氏肌营养不良症（DMD）非常相似，不过显著不同的是未发现肌酸激酶水平升高。结合最近关于细胞内能量机制变化可能损害细胞膜通透性的观点对这些发现进行了讨论。
