[Role of the serial determination of myoglobin, enzymes and isoenzymes in the early diagnosis of myocardial infarction].

Seventy-eight patients with myocardial infarction had been admitted to the intensive care unit not later than 5 h after the beginning of illness. The levels of myoglobin, CPK, LDH, AST, ALT, MB CPK and LDH1 were determined in the blood serum of the patients in the time course during the first 24 hours of hospitalization. All patients showed considerable increase of myoglobin level in the blood serum. In myocardial infarction the level of myoglobin is enhanced significantly earlier than all the other indices, and reached its maximum figure also earlier. In the majority of cases its content reverts to normal at the beginning or in the middle of the second day. In 10 patients with the spread of the primary focus of lesion a repeated peak of myoglobin rise was recorded a few hours after the painful attack. In cases complicated during the course of illness by circulatory insufficiency hypermyoglobinemia was observed during a much greater period of time. Hypermyoglobinemia is the most sensitive and the earliest test of myocardial infarction compared to other biochemical tests.