Vanherweghem J L, Linkowski P, Jadot C, Mendlewicz J
Proc Eur Dial Transplant Assoc. 1979;16:148-54.
The therapeutic effects of haemodialysis were evaluated in schizophrenic patients using a double blind procedure. Twelve patients were diagnosed as acute schizophrenics according to Feighner's criteria for psychopathology. After obtaining informed consent, the patients were randomly assigned to active haemodialysis (AD) or sham dialysis (SD). An 8 days "drug washout period" was followed by AD or SD treatment of 4 weeks (two 5 hours sessions per week) and psychopathological evaluations were performed regularly in a blind fashion using the Brief Psychiatry Rating Scale (BPRS) and the Comprehensive Psychopathological Rating Scale (CPRS). Nine of the 12 patients were improved by both extracorporeal procedures with or without active dialysis. No significant difference appeared however between both groups in the rate and degree of improvement of nuclear symptoms of schizophrenia. Nevertheless, AD was significantly more efficient in relieving affective symptomatology, suggesting the potential involvement of some endogenous dialysable substance (s) in the pathogenesis of mood disturbances in schizophrenia.
采用双盲程序评估血液透析对精神分裂症患者的治疗效果。根据费格纳精神病理学标准，12名患者被诊断为急性精神分裂症患者。在获得知情同意后，患者被随机分配到进行主动血液透析（AD）或假透析（SD）。经过8天的“药物洗脱期”后，进行为期4周的AD或SD治疗（每周两次，每次5小时），并使用简明精神病评定量表（BPRS）和综合精神病理学评定量表（CPRS）以盲法定期进行精神病理学评估。12名患者中有9名患者无论是否进行主动透析，体外治疗均有改善。然而，两组在精神分裂症核心症状的改善率和改善程度上没有显著差异。尽管如此，AD在缓解情感症状方面明显更有效，这表明某些内源性可透析物质可能参与了精神分裂症情绪障碍的发病机制。
