Leber H W, Uviss T, Prenter A
Proc Eur Dial Transplant Assoc. 1979;16:232-7.
After bilateral or subtotal nephrectomy male rats were given intraperitoneal injections of the plasticiser di-2-ethylhexylphthalate (DEHP) at differing time intervals in doses that do not affect the liver of normal rats. 200mg DEHP/100g body weight had no influence on the parameters measured. After administering 7 x 200mg/100g body weight for 14 days, liver weight and in vitro activity of the mixed function oxidation system increased significantly. In addition, the hexobarbital sleeping time decreased, indicating a stimulation of the activity of drug metabolising enzymes in vivo. Similar results were obtained after the administration of 56 x 50mg DEHP/100g body weight for 19 weeks. It is concluded that uraemic rats are more susceptible to inducing effects, but that the DEHP toxicity is of little importance.
对雄性大鼠进行双侧或次全肾切除术后，在不同时间间隔给它们腹腔注射增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP），剂量不会影响正常大鼠的肝脏。200mg DEHP/100g体重对所测参数无影响。在以200mg/100g体重给药7次，持续14天后，肝脏重量和混合功能氧化系统的体外活性显著增加。此外，己巴比妥睡眠时间缩短，表明体内药物代谢酶的活性受到刺激。在以50mg DEHP/100g体重给药56次，持续19周后也得到了类似结果。得出的结论是，尿毒症大鼠更容易受到诱导作用的影响，但DEHP的毒性不太重要。
