用二甲基亚砜（DMSO）治疗肾淀粉样变性
Treatment of renal amyloidosis with dimethylsulphoxide (DMSO).
作者信息
van Rijswijk M H, Donker A J, Ruinen L, Marrink J
出版信息
Proc Eur Dial Transplant Assoc. 1979;16:500-5.
Amyloid fibrils can be dissolved by dimethylsulphoxide (DMSO) in vitro and in vivo. This prompted us to investigate the therapeutic value of DMSO in renal failure caused by amyloidosis. Two patients with renal failure caused by secondary amyloidosis due to rheumatoid arthritis, showed a remarkable improvement of renal function. The effect of DMSO in amyloidosis secondary to rheumatoid arthritis seems to depend on its anti-inflammatory action, resulting in a decrease in amyloid formation. No evidence was found for an increase in amyloid degradation. The effect of DMSO in primary amyloidosis was inconclusive.
淀粉样原纤维在体外和体内均可被二甲基亚砜（DMSO）溶解。这促使我们研究DMSO在淀粉样变性所致肾衰竭中的治疗价值。两名因类风湿性关节炎继发淀粉样变性而导致肾衰竭的患者，肾功能有显著改善。DMSO对类风湿性关节炎继发淀粉样变性的作用似乎取决于其抗炎作用，从而导致淀粉样蛋白形成减少。未发现有淀粉样蛋白降解增加的证据。DMSO对原发性淀粉样变性的作用尚无定论。
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