Yen S H, Dahl D, Schachner M, Shelanski M L
Proc Natl Acad Sci U S A. 1976 Feb;73(2):529-33. doi: 10.1073/pnas.73.2.529.
Intermediate filaments-cytoplasmic filaments with a diameter of 8-9 nm-have been described in a large variety of cell types. In this study, the subunit protein of the neurofilament and the presumptive subunit of the astroglial filament are compared by immunological and biochemical methods and are found to be very similar. Strong crossreactions are also found between these proteins in a variety of mammalian species. These results suggest that the intermediate filaments may, like microtubules and microfilaments, represent a highly conserved and widely distributed fibrous protein system.
中间丝——直径为8 - 9纳米的细胞质细丝——已在多种细胞类型中被描述。在本研究中，通过免疫和生化方法对神经丝的亚基蛋白和星形胶质细胞丝的假定亚基进行了比较，发现它们非常相似。在多种哺乳动物物种中，这些蛋白之间也发现了强烈的交叉反应。这些结果表明，中间丝可能像微管和微丝一样，代表了一种高度保守且广泛分布的纤维蛋白系统。
