Maxwell J D, McKiddie M T, Ferguson A, Buchanan K D
Gut. 1970 Nov;11(11):962-5. doi: 10.1136/gut.11.11.962.
Plasma insulin levels were determined following oral glucose in 12 patients with adult coeliac disease, after oral lactose in four patients with alactasia, and in age-matched control subjects. In coeliac patients the insulin response was greater than expected from the small rise in blood sugar, and no correlation was found between plasma insulin and sugar levels at any period during the test. The separation of the plasma insulin curve from the blood sugar curve after glucose is in keeping with the concept that a factor responsible for stimulating insulin secretion is released from the gut during or after absorption of glucose. In patients with selective lactose malabsorption (alactasia) administration of lactose by mouth failed to elicit any insulin response, indicating that the insulin-releasing effect of the bowel is not activated merely by the presence of intraluminal carbohydrate.
测定了12例成人乳糜泻患者口服葡萄糖后、4例乳糖酶缺乏患者口服乳糖后以及年龄匹配的对照受试者的血浆胰岛素水平。在乳糜泻患者中，胰岛素反应大于血糖小幅升高所预期的反应，并且在测试的任何时间段内，血浆胰岛素水平与血糖水平之间均未发现相关性。葡萄糖后血浆胰岛素曲线与血糖曲线分离，这与以下概念相符：在葡萄糖吸收期间或之后，肠道会释放一种负责刺激胰岛素分泌的因子。在选择性乳糖吸收不良（乳糖酶缺乏）患者中，口服乳糖未能引发任何胰岛素反应，这表明肠道的胰岛素释放作用并非仅由肠腔内碳水化合物的存在而激活。
