Kettner W, Quednow B, Wilckens H, Walther H
Z Gesamte Inn Med. 1979 Oct 15;34(20):suppl 282-4.
For the therapy of disturbances of the cardiac rhythm with phenytoin 3 different dosage regimes are examined, in which cases an oral application of phenytoin proves as not suitable. Only by a stepped infusion with following oral treatment a rapid saturation and therapeutically effective serum levels are achieved which are decisive for the effectiveness of the therapeutic measures.
对于使用苯妥英钠治疗心律失常,研究了3种不同的给药方案,在这些情况下,口服苯妥英钠被证明不合适。只有通过逐步静脉输注并随后进行口服治疗,才能实现快速饱和并达到治疗有效的血清水平,这对治疗措施的有效性至关重要。