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急性冠状动脉疾病中的静脉注射硝酸甘油

Intravenous nitroglycerin in acute coronary artery disease.

作者信息

Marrott P K, Nairn P L, Dawson C J, Martin S M

出版信息

N Z Med J. 1982 Sep 22;95(716):663-6.

PMID:6813780
Abstract

Intravenous nitroglycerin (IVNG) was used in 12 instances (11 patients) to relieve pain, following myocardial infarction or unstable angina. The strength of IVNG infusion could be easily controlled and relief of pain was prompt and satisfactory. Excessive tachycardia or severe headache was not encountered and marked hypotension was seen in one patient only. This patient had three vessel coronary artery disease, extensive myocardial damage and vein graft closure. Cardiovascular stability was provided by IVNG, prior to and during cardiac catheterisation and cineangiography, transportation to another hospital and vein graft surgery. IVNG appears to be a safe and effective drug in the management of patients with acute coronary artery disease (unstable angina and myocardial infarction). In those with both right and left ventricular wall infarction, however, the usefulness of IVNG needs to be established.

摘要

静脉注射硝酸甘油(IVNG)用于12例(11名患者)心肌梗死或不稳定型心绞痛后缓解疼痛。IVNG输注的剂量易于控制,疼痛缓解迅速且令人满意。未出现过度心动过速或严重头痛,仅1例患者出现明显低血压。该患者患有三支冠状动脉疾病、广泛心肌损伤和静脉移植物闭塞。在心脏导管插入术和心血管造影术之前、期间、转送至另一家医院以及静脉移植物手术过程中,IVNG维持了心血管稳定性。IVNG似乎是治疗急性冠状动脉疾病(不稳定型心绞痛和心肌梗死)患者的一种安全有效的药物。然而,在同时患有右心室和左心室壁梗死的患者中,IVNG的有效性尚需确定。

相似文献

1
Intravenous nitroglycerin in acute coronary artery disease.急性冠状动脉疾病中的静脉注射硝酸甘油
N Z Med J. 1982 Sep 22;95(716):663-6.
2
[Effect of intravenous administration of nitroglycerin on the indicators of central hemodynamics in patients with acute myocardial infarction].静脉注射硝酸甘油对急性心肌梗死患者中心血流动力学指标的影响
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1983;6(2):49-54.
3
Parenteral nitroglycerin: clinical usefulness and limitations.胃肠外硝酸甘油:临床应用价值与局限性
Cardiovasc Clin. 1984;14(3):111-8.
4
API expert consensus document on management of ischemic heart disease.缺血性心脏病管理的API专家共识文件
J Assoc Physicians India. 2006 Jun;54:469-80.
5
[Intravenous administration of nitroglycerin to patients with unstable stenocardia].
Ter Arkh. 1986;58(5):120-4.
6
Polyvinylchloride containers do not influence the hemodynamic response to intravenous nitroglycerin.聚氯乙烯容器不会影响静脉注射硝酸甘油后的血流动力学反应。
Can J Hosp Pharm. 1993 Aug;46(4):165-70.
7
Therapeutic scope of intravenous nitroglycerin.静脉注射硝酸甘油的治疗范围。
Angiology. 1982 May;33(5):287-93. doi: 10.1177/000331978203300501.
8
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Arzneimittelforschung. 1970 Mar;20:459-60.
9
Nitroglycerin infusion after percutaneous coronary intervention does not influence short- and long-term outcome--a prospective NAPI (Nitroglycerin Administration after Percutaneous Intervention) study.经皮冠状动脉介入治疗后静脉输注硝酸甘油不影响短期和长期预后——一项前瞻性NAPI(经皮介入后硝酸甘油给药)研究
Kardiol Pol. 2007 Jul;65(7):789-803; discussion 804-5.
10
Withdrawal of intravenous glyceryl trinitrate: absence of rebound phenomena with transition to oral isosorbide dinitrate.静脉注射硝酸甘油停药:转换为口服硝酸异山梨酯时无反跳现象。
Clin Exp Pharmacol Physiol. 2005 Apr;32(4):269-72. doi: 10.1111/j.1440-1681.2005.04182.x.

引用本文的文献

1
Intravenous glyceryl trinitrate (nitroglycerin). A review of its pharmacological properties and therapeutic efficacy.静脉注射硝酸甘油。对其药理特性和治疗效果的综述。
Drugs. 1984 Jan;27(1):45-80. doi: 10.2165/00003495-198427010-00003.