Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B 12 deficiency, on fatty acid synthesis.

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作者信息

Cardinale G J, Carty T J, Abeles R H

出版信息

J Biol Chem. 1970 Aug 10;245(15):3771-5.

PMID:5492945

Abstract

摘要

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Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B 12 deficiency, on fatty acid synthesis.

J Biol Chem. 1970 Aug 10;245(15):3771-5.

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The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA.支链脂肪酸的合成受到乙基丙二酸单酰辅酶 A 和甲基丙二酸单酰辅酶 A 的酶脱羧作用的限制。

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The use of clustering techniques in the elucidation or confirmation of metabolic pathways. Application to the branched-chain fatty acids present in the milk fat of lactating goats.聚类技术在阐明或确认代谢途径中的应用。应用于泌乳山羊乳脂肪中存在的支链脂肪酸。

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Utilization of methylmalonate for the synthesis of branched-chain fatty acids by preparations of chicken liver and sheep adipose tissue.利用丙二酸单甲酯通过鸡肝和羊脂肪组织制剂合成支链脂肪酸。

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Possible interrelationship between vitamins E and b12 in the disturbance in methylmalonate metabolism in vitamin E deficiency.维生素E缺乏时维生素E与维生素B12在甲基丙二酸代谢紊乱中可能存在的相互关系。

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