利用丙二酸单甲酯通过鸡肝和羊脂肪组织制剂合成支链脂肪酸。
Utilization of methylmalonate for the synthesis of branched-chain fatty acids by preparations of chicken liver and sheep adipose tissue.
作者信息
Scaife J R, Wahle K W, Garton G A
出版信息
Biochem J. 1978 Dec 15;176(3):799-804. doi: 10.1042/bj1760799.
Abstract
- The utilization of methyl[2-14C]malonyl-CoA for fatty acid synthesis was investigated using synthetase preparations from chicken liver and sheep adipose tissue. 2. The rate of fatty acid synthesis from acetyl-CoA and malonyl-CoA was greatly diminished in the presence of methylmalonyl-CoA. 3. In the absence of malonyl-CoA, methylmalonyl-CoA was utilized for fatty acid synthesis only very slowly by the synthetase from sheep adipose tissue and not at all by that from chicken liver. 4. Despite the inhibitory effect of methylmalonyl-CoA on fatty acid synthesis from malonyl-CoA, it was utilized by the synthetase preparations from both species to produce a complex mixture of methyl-branched fatty acids.
摘要
- 使用鸡肝和绵羊脂肪组织的合成酶制剂研究了甲基[2-¹⁴C]丙二酰辅酶A在脂肪酸合成中的利用情况。2. 在甲基丙二酰辅酶A存在的情况下，由乙酰辅酶A和丙二酰辅酶A合成脂肪酸的速率大大降低。3. 在没有丙二酰辅酶A的情况下，甲基丙二酰辅酶A仅被绵羊脂肪组织的合成酶非常缓慢地用于脂肪酸合成，而鸡肝的合成酶则完全不利用它。4. 尽管甲基丙二酰辅酶A对由丙二酰辅酶A合成脂肪酸有抑制作用，但两种物种的合成酶制剂都利用它来产生甲基支链脂肪酸的复杂混合物。
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