Cuschieri A, Onabanjo A O, James P B
Br J Exp Pathol. 1970 Dec;51(6):611-6.
The experiments recorded in this work were conducted in apparently healthy subjects at different environmental conditions to study bradykininogen utilization and the arterio-venous (A-V) difference in blood. In the process of our studies, a significant A-V difference of kininogen values was obtained in the hand at an ambient temperature of 21·3° in individuals under general anaesthesia. During periods of cold immersion, the venous bradykininogen rises above the initial values. The increase is thought to be the result of admixture of venous and arterial blood. Similarly, increased kininogen utilization occurred during cold vasodilatation of the hand. This rise provides indirect evidence of kinin release during this vascular phenomenon. During the recovery phase after cold vasodilatation, the total mean venous kininogen level was found to be statistically similar to that obtained at the initial phase. Possible reasons for the above significant differences have been discussed.
本研究记录的实验是在不同环境条件下对看似健康的受试者进行的，以研究缓激肽原的利用情况以及血液中的动静脉（A-V）差异。在我们的研究过程中，在全身麻醉下的个体中，于21.3°的环境温度下，手部获得了激肽原值的显著动静脉差异。在冷浸期间，静脉缓激肽原升高至初始值以上。这种升高被认为是静脉血与动脉血混合的结果。同样，手部冷血管扩张期间激肽原利用增加。这种升高为这种血管现象期间激肽释放提供了间接证据。在冷血管扩张后的恢复阶段，发现静脉激肽原总平均水平在统计学上与初始阶段相似。已经讨论了上述显著差异的可能原因。
