用聚肌苷酸-聚胞苷酸和环磷酰胺抑制小鼠狼疮中针对核酸的抗体
Suppression of antibodies to nucleic acids with polyinosinic-polycytidylic acid and cyclophosphamide in murine lupus.
作者信息
Steinberg A D, Talal N
出版信息
Clin Exp Immunol. 1970 Nov;7(5):687-91.
Abstract
NZB/NZW mice with active lupus were treated with polyinosinic·polycytidylic acid, a synthetic double stranded RNA, followed by cyclophosphamide to induce immunologic tolerance to nucleic acids. This combined regimen reduced serum antibodies to RNA and DNA to a greater degree than did cyclophosphamide alone. This report demonstrates that a specific form of immunotherapy can be successfully employed to treat the serologic abnormalities of murine lupus.
摘要
对患有活动性狼疮的NZB/NZW小鼠，先用聚肌苷酸-聚胞苷酸（一种合成双链RNA）进行治疗，随后给予环磷酰胺以诱导对核酸的免疫耐受。与单独使用环磷酰胺相比，这种联合方案能更大程度地降低血清中针对RNA和DNA的抗体水平。本报告表明，一种特定形式的免疫疗法可成功用于治疗小鼠狼疮的血清学异常。
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本文引用的文献
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INHIBITION OF HEMAGGLUTININ SYNTHESIS BY CYTOXAN.环磷酰胺对血凝素合成的抑制作用
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Measurement of serum DNA-binding activity in systemic lupus erythematosus.系统性红斑狼疮患者血清DNA结合活性的测定
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Science. 1970 Feb 6;167(3919):870-1. doi: 10.1126/science.167.3919.870.
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The pathogenesis of autoimmunity in New Zealand mice, I. Induction of antinucleic acid antibodies by polyinosinic-polycytidylic acid.新西兰小鼠自身免疫的发病机制，I. 聚肌苷酸-聚胞苷酸诱导抗核酸抗体的产生
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Further implication of murine leukemia-like virs in the disorders of NZB mice.鼠白血病样病毒在新西兰黑小鼠疾病中的进一步影响。
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Pathogenesis of the glomerulonephritis of NZB/W mice.NZB/W小鼠肾小球肾炎的发病机制。
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Immunological studies concerning the nephritis of systemic lupus erythematosus.关于系统性红斑狼疮肾炎的免疫学研究。
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