Mahon W A, Wittenberg J V, Tuffnel P G
Can Med Assoc J. 1970 Nov 7;103(10):1031-4.
Doxycycline, a recently synthesized analogue of tetracycline, was given to 16 patients with normal renal function and to 14 patients with severely impaired renal function. Serum concentrations in the two groups following a single dose were followed after absorption. The rate of clearance from the plasma following a single dose did not differ significantly in the two groups despite low urinary concentrations in patients with renal failure. No accumulation of doxycycline occurred in the serum of three normal patients or of nine patients with renal failure when treated with either 200 mg. daily or 200 mg. initially followed by 100 mg. daily for up to 15 days.
强力霉素是最近合成的四环素类似物，给予了16例肾功能正常的患者和14例肾功能严重受损的患者。吸收后跟踪了两组单次给药后的血清浓度。尽管肾衰竭患者尿中浓度较低，但两组单次给药后血浆清除率无显著差异。3例正常患者和9例肾衰竭患者在接受每日200mg或初始200mg随后每日100mg持续15天的治疗时，血清中未出现强力霉素蓄积。
