Laurens A, Lagrosse J P, Laissy J P, Fabresse F X, Timsit J C, Martoia R
Ann Med Interne (Paris). 1979;130(11):523-30.
The authors review 13 cases of bone localisation of Hodgkin's disease taken from 120 case-reports, and compare the findings with those reported in the published literature. The frequency of bone lesions in this series was 18%. Initial signs were clinical in one half of the cases and radiological or scintigraphic in the other half. Early diagnosis of bone lesions was more frequently made in this series than late discovery of bone locations; the lesions ware more frequently present in the spine, the pelvis, and the sternum; the usual appearance was osteolytic or mixed, lytic and condensed. Scintigraphy is a reliable early diagnostic procedure, as is medullary biopsy which has become essential for the investigation of extension of the lesions. An inflammatory syndrome is present in most cases. In this series, bone lesions usually were of haematogenic origin and were mainly of the scleronodular histological type. Definite recovery was obtained in more than half of the cases. In the other patients, the bone lesions coincided with a long disease course, were never the reason for great concern, and were never directly responsible for death in the 3 patients that died.
作者回顾了从120例病例报告中选取的13例霍奇金病骨转移病例，并将研究结果与已发表文献中的报告进行比较。该系列中骨病变的发生率为18%。一半病例的初始症状为临床症状，另一半为放射学或闪烁扫描症状。与晚期发现骨转移相比，该系列中骨病变的早期诊断更为常见；病变更常见于脊柱、骨盆和胸骨；常见表现为溶骨性或混合性，既有溶骨又有骨质硬化。闪烁扫描是一种可靠的早期诊断方法，骨髓活检对于病变范围的研究也至关重要。大多数病例存在炎症综合征。在该系列中，骨病变通常起源于血行转移，主要为硬化结节组织学类型。超过一半的病例获得了明确缓解。在其他患者中，骨病变与病程较长有关，从未引起严重关注，并且在3例死亡患者中，骨病变从未直接导致死亡。
