Feherty P, Robertson D M, Waynforth H B, Kellie A E
Biochem J. 1970 Dec;120(4):837-44. doi: 10.1042/bj1200837.
A quantitative method was used to determine the concentration of high-affinity oestradiol-receptor sites in rat uterine supernatant preparations under various physiological conditions. Cyclic changes in concentration were observed during the oestrous cycle, with a maximum occurring in late dioestrus. The changes followed a similar pattern in endometrium and myometrium, although concentrations were higher in the former. In pseudopregnancy the concentration was initially low, rising to a maximum on the tenth day. In early pregnancy a high concentration of receptor was found to be associated with the developing placenta, but this declined in later stages of pregnancy. After ovariectomy or combined ovariectomy and adrenalectomy the receptor concentration remained at a constant low value that could be increased by treatment with oestradiol. The receptor concentration was considerably higher in immature than in adult uteri.
采用定量方法测定不同生理条件下大鼠子宫上清液制剂中高亲和力雌二醇受体位点的浓度。在发情周期中观察到浓度的周期性变化，在动情后期出现最大值。子宫内膜和子宫肌层的变化遵循相似模式，尽管前者的浓度更高。在假孕时，浓度最初较低，在第10天升至最高。在妊娠早期，发现高浓度的受体与发育中的胎盘相关，但在妊娠后期下降。卵巢切除或卵巢切除与肾上腺切除联合术后，受体浓度保持在恒定的低值，用雌二醇治疗可使其升高。未成熟子宫中的受体浓度明显高于成年子宫。
