Nimmo A J, Whitaker E M, Carstairs J R, Morrison J F
Department of Physiology, University of Leeds.
J Endocrinol. 1989 Aug;122(2):R1-4.
It has been proposed that the change in sensitivity of the uterus to catecholamines during the oestrous cycle may result from changes in beta-adrenoceptor density in the myometrium. In the present work we applied the technique of light-microscopic autoradiography using the radioligand [125I]iodocyanopindolol to study the density and distribution of beta-adrenoceptors in the rat uterus during the normal oestrous cycle, following ovariectomy, and after ovariectomy with oestradiol replacement. We found that beta-adrenoceptor density in the endometrium, but not the myometrium, varied during the oestrous cycle, being highest during pro-oestrous. The endometrium of the ovariectomized rats was devoid of any beta-adrenoceptors, whilst that of the oestradiol-treated rats was very intensely labelled. Following ovariectomy there was an increase in beta-adrenoceptor density in the myometrium, but this was not observed in the animals given oestradiol replacement. It appears that both the presence and density of beta-adrenoceptors in rat endometrium is dependent on circulating oestrogens.
有人提出，发情周期中子宫对儿茶酚胺敏感性的变化可能是由于子宫肌层中β - 肾上腺素能受体密度的改变所致。在本研究中，我们应用放射性配体[125I]碘氰吲哚洛尔的光学显微镜放射自显影技术，研究正常发情周期、卵巢切除术后以及卵巢切除并用雌二醇替代后的大鼠子宫中β - 肾上腺素能受体的密度和分布。我们发现，发情周期中子宫内膜而非子宫肌层的β - 肾上腺素能受体密度会发生变化，在发情前期最高。卵巢切除大鼠的子宫内膜没有任何β - 肾上腺素能受体，而接受雌二醇治疗的大鼠的子宫内膜则有非常强烈的标记。卵巢切除后，子宫肌层中β - 肾上腺素能受体密度增加，但在给予雌二醇替代的动物中未观察到这种情况。看来大鼠子宫内膜中β - 肾上腺素能受体的存在和密度都依赖于循环中的雌激素。
