Igartua García L, Sánchez Torres G, González Mariscal G, Etulain Maldonado F, Méndez Venegas J
Arch Inst Cardiol Mex. 1979 Nov-Dec;49(6):1073-89.
Twelve chemical rhyzolisis (surgical instilation of 10 c.c. of 15% NaCl solution) of trigeminal nerve were performed in 11 patients with trigeminal neuralgia resistent to medical treatment. Before and at least in the first 30 minutes after instilation the following parameters were monitorized: electrocardiogram, electroencephalogram, intrarradial arterial pressure and venous central pressure. In 10 cases after a 2.8 +/- 2.4 seg. latency period the following arrhythmias appeared (in paragraphs number of cases): sinus bradicardia, sinoauricular block, sinus arrest, atrial-ventricular block and atrial pacemaker migration. During sinus arrest (8 episodes in 4 cases; mean duration 17.6 secs.) slow, high voltage waves appeared in the electroencephalographic tracings. Ventricular scapes were not seen at the end of the sinus pauses. In 6 cases after this slow arrhythmic phase the following arrhythmias were observed: ventricular premature beats, atrial premature beats, sinus tachycardia, bidirectional ventricular tachycardia, and nodal tachycardia. All cases exhibited an elevation of mean arterial pressure after instilation of the nerve which was preceded by a short period of hypertension in 4 occasions. Average and standard deviations changes of systolic, diastolic and mean blood pressure (mm of Hg), pulse (beats/minute) and central venous pressure (cms of H2O) during the procedure were 46.7 +/- 29.3, 23.0 +/- 13.3, 34.1 +/- 16.4, 25.8 +/- 16.2 and 6.6 +/- 5.8, respectively (p less than or equal to 0.001) in all changes but the last ones, less than or equal to 0.05). Physiopathologic considerations of this autonomic crises are done.
对11例药物治疗无效的三叉神经痛患者进行了12次三叉神经化学性溶解术（手术注入10毫升15%氯化钠溶液）。在注入前及注入后至少30分钟内监测以下参数：心电图、脑电图、桡动脉血压和中心静脉压。10例患者在2.8±2.4秒的潜伏期后出现以下心律失常（按病例数计）：窦性心动过缓、窦房阻滞、窦性停搏、房室阻滞和心房起搏器移位。在窦性停搏期间（4例患者出现8次发作；平均持续时间17.6秒），脑电图描记图上出现缓慢、高电压波。窦性停搏结束时未见室性逸搏。在这个缓慢心律失常阶段后，6例患者观察到以下心律失常：室性早搏、房性早搏、窦性心动过速、双向室性心动过速和结性心动过速。所有病例在神经注入后均出现平均动脉压升高，其中4例在升高前有短时间高血压。手术过程中收缩压、舒张压和平均血压（毫米汞柱）、脉搏（次/分钟）和中心静脉压（厘米水柱）的平均变化及标准差分别为46.7±29.3、23.0±13.3、34.1±16.4、25.8±16.2和6.6±5.8（除最后一项p≤0.05外，所有变化p≤0.001）。对这种自主神经危象进行了病理生理学分析。
