某些甾体化合物在成年和幼虫青蛙中的生物活性。

Biological activity of some steroidal compounds in the adult and larval frogs.

作者信息

Iela L, Rastogi R K, Chieffi G

出版信息

Steroids. 1975 Nov;26(5):663-9. doi: 10.1016/0039-128x(75)90058-6.

Abstract

Four steroids were tested for their biological activity, using the sex-steroid-dependent redevelopment of the secondary sex characteristics in adult frogs and gonadal sex differentiation in larval frogs as end points. In adult frogs, 19-norprogesterone and 6-chloro-17alpha-hydroxy-4, 6-pregnadiene-3,20-dione had antiandrogenic and antiestrogenic effects. 2alpha, 17alpha-Dimethyl-DHT and 2alpha-methyl-DHT were potent androgens and effective antiestrogens. In the larval frogs, all four compounds had a masculinizing effect upon the undifferentiated gonads.

摘要

以成年青蛙次级性征的性类固醇依赖性重新发育和幼体青蛙性腺性别分化作为终点，对四种类固醇的生物活性进行了测试。在成年青蛙中，19-去甲孕酮和6-氯-17α-羟基-4,6-孕二烯-3,20-二酮具有抗雄激素和抗雌激素作用。2α,17α-二甲基双氢睾酮和2α-甲基双氢睾酮是强效雄激素和有效的抗雌激素。在幼体青蛙中，所有四种化合物对未分化的性腺都有雄性化作用。