Huchon D
Ann Endocrinol (Paris). 1977 May-Jun;38(3):223-33.
Young Discoglossus pictus Otth (Amphibian, Anura) received either male hormone (testosterone or testosterone propionate) or the anti-steroid anti-androgen cyproterone acetate. The male hormone had a masculinizing effect on the genital tract when observed four months later and, paradoxically, the anti-androgen had the same effect: -- Hypertrophy of the posterior segment of the Wolffian ducts yields seminal vesicles, whose wall is covered with a flat epithelium after androgen treatment. Cyproterone acetate treatment, however, results in the cytological differentiation of this epithelium. -- Müllerian ducts persist in a vestigial form. In this respect, the inhibitory action of cyproterone acetate is stronger than that of the male hormone.
幼年的花姬蛙(两栖纲,无尾目)接受了雄性激素(睾酮或丙酸睾酮)或抗类固醇抗雄激素醋酸环丙孕酮的处理。四个月后观察发现,雄性激素对生殖道有雄性化作用,而矛盾的是,抗雄激素也有同样的效果:——雄激素处理后,沃尔夫管后段肥大形成精囊,其壁由扁平上皮覆盖。然而,醋酸环丙孕酮处理导致该上皮细胞发生细胞学分化。——缪勒氏管以退化的形式留存。在这方面,醋酸环丙孕酮的抑制作用比雄性激素更强。