Pirani R, Tomasi A M, Gruppillo P, Masoni A
G Ital Cardiol. 1979;9(12):1345-50.
Fifty nine patients suffering from slight or moderate essential arterial hypertension underwent hypotensive treatment. After one week of wash-out, therapeutic administration of tienilic acid in doses of 500 mg per day was begun; in the third week we combined a non diuretic hypotensive drug (prazosin, propranolol, alfametil-dopa). At the beginning of the study all patients underwent an ECG, a clinical cardiological examiniation, funduscopy examination, funduscopy examination, a heart X - ray in 3 standard positions and a routine blood test which was repeated during and at the end of the treatment. The patients' blood pressure taken in an upright and supine position, showed statistically significant reductions for both systolic and diastolic values in all 3 groups, whereas the routine blood tests gave evidence of a marked reduction in the uriacid, triglycerides and potassium levels. In order to correct the latter we had to administer high oral doses of potassium, and in one case admittance to hospital was necessary since the potassium level was lower then 2.5 mEq/l.
59名患有轻度或中度原发性动脉高血压的患者接受了降压治疗。经过一周的洗脱期后，开始每天服用500毫克替尼酸进行治疗；在第三周，我们联合使用了一种非利尿降压药（哌唑嗪、普萘洛尔、阿法甲基多巴）。在研究开始时，所有患者都进行了心电图检查、临床心脏检查、眼底镜检查、心脏X线三个标准体位检查以及常规血液检查，这些检查在治疗期间和结束时重复进行。患者直立位和仰卧位的血压显示，所有三组的收缩压和舒张压值均有统计学意义的降低，而常规血液检查显示尿酸、甘油三酯和钾水平明显降低。为了纠正后者，我们不得不口服高剂量的钾，在一个病例中，由于钾水平低于2.5毫当量/升，患者需要住院治疗。
