正常碳酸血症和高碳酸血症时局部脑血管对急性缺血的反应。一项在狒狒身上进行的实验研究。
Regional cerebrovascular responses to acute ischaemia in normocapnia and hypercapnia. An experimental study in baboons.
作者信息
Symon L
出版信息
J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):756-62. doi: 10.1136/jnnp.33.6.756.
Abstract
Arterial and venous pressures have been measured in the cortical circulation of baboons. Arterial perfusion pressure was found to be relatively lower in hypercapnia than in normocapnia, while venous pressure was higher in hypercapnia than normocapnia. In hypercapnia, during middle cerebral occlusion, the arteriovenous pressure differences virtually disappeared and evidence of collateral inflow to the ischaemic zone was absent. Reactive hyperaemia after middle cerebral occlusion was reduced or abolished in hypercapnia. The significance of these findings in relation to treatment of ischaemic vascular disease with CO(2) is discussed.
摘要
已经在狒狒的皮质循环中测量了动脉压和静脉压。发现高碳酸血症时的动脉灌注压比正常碳酸血症时相对较低，而高碳酸血症时的静脉压比正常碳酸血症时更高。在高碳酸血症中，大脑中动脉闭塞期间，动静脉压差几乎消失，并且没有向缺血区侧支血流的证据。大脑中动脉闭塞后的反应性充血在高碳酸血症中减少或消失。讨论了这些发现与用二氧化碳治疗缺血性血管疾病的相关性。
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Regional cerebrovascular responses to acute ischaemia in normocapnia and hypercapnia. An experimental study in baboons.正常碳酸血症和高碳酸血症时局部脑血管对急性缺血的反应。一项在狒狒身上进行的实验研究。
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