在下丘脑电刺激过程中采集的大鼠垂体门脉血中的促黄体生成激素释放因子。
Luteinizing hormone releasing factor in rat hypophysial portal blood collected during electrical stimulation of the hypothalamus.
作者信息
Harris G W, Ruf K B
出版信息
J Physiol. 1970 May;208(1):243-50. doi: 10.1113/jphysiol.1970.sp009116.
Abstract
- Ovulation was induced in Nembutal-blocked pro-oestrous rats by electrical stimulation of the hypothalamus.2. The same type of electrical stimulation was applied during the collection of hypophysial portal blood.3. Pooled hypophysial portal plasma from donors in pro-oestrus, oestrus and met-oestrus was assayed for ovarian ascorbic acid depleting (OAAD) activity.4. Electrical stimulation of the hypothalamus increased the OAAD activity, believed to be due to luteinizing hormone releasing factor (LRF), in pro-oestrus and met-oestrus, but not in oestrus.5. It is concluded that the hypothalamic nerve fibres responsible for releasing LRF into the hypophysial portal vessels are depleted of their store of this releasing factor, or are refractory to electrical stimulation, during oestrus.
摘要
通过电刺激下丘脑，在戊巴比妥麻醉的动情前期大鼠中诱导排卵。
在采集垂体门脉血期间施加相同类型的电刺激。
对来自动情前期、发情期和动情后期供体的合并垂体门脉血浆进行卵巢抗坏血酸消耗（OAAD）活性测定。
电刺激下丘脑会增加动情前期和动情后期的OAAD活性，据信这是由于促黄体生成素释放因子（LRF）所致，但在发情期不会增加。
得出的结论是，在发情期，负责将LRF释放到垂体门脉血管中的下丘脑神经纤维，其这种释放因子的储备已耗尽，或者对电刺激不敏感。
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