节前瞳孔收缩神经元的活动特征

The activity characteristics of the preganglionic pupilloconstrictor neurones.

作者信息

Sillito A M, Zbrozyna A W

出版信息

J Physiol. 1970 Dec;211(3):767-79. doi: 10.1113/jphysiol.1970.sp009303.

DOI:10.1113/jphysiol.1970.sp009303

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1396085/

Abstract

Recordings have been made of pupilloconstrictor unit activity within the small-celled component of the oculomotor nucleus of the cat. The identity of these neurones was determined by testing unit responses to a sequence of stimuli which produced dilation and constriction of the sympathectomized pupil.2. The frequency range of unit activity was from 0 to 28/sec. A maximal constriction of the pupil was maintained by unit activity in the region of 8/sec. The resting level of unit activity under chloralose anaesthesia was typically in the range 6-10/sec.3. Stimulation in the defence area of the hypothalamus produced a maximal pupillodilation associated with a complete inhibition of unit activity and a block of the light reflex response.4. Onset of retinal illumination produced a burst discharge followed by a transient silent period and then an over-all increase in the rate of activity.5. Cessation of retinal illumination produced a post-excitatory depression of unit activity lasting from 190 to 700 msec. It is suggested that this effect is produced by retinal afferents activated by light ;off' that exert an inhibitory influence on the pupilloconstrictor neurones.

摘要

已对猫动眼神经核小细胞成分内的瞳孔收缩单位活动进行了记录。通过测试单位对一系列使交感神经切除的瞳孔产生扩张和收缩的刺激的反应，确定了这些神经元的身份。
单位活动的频率范围为0至28次/秒。在8次/秒左右的单位活动维持着瞳孔的最大收缩。在水合氯醛麻醉下，单位活动的静息水平通常在6至10次/秒范围内。
在下丘脑防御区进行刺激会产生最大瞳孔扩张，同时伴有单位活动的完全抑制和光反射反应的阻断。
视网膜光照开始时会产生一阵放电，随后是短暂的静息期，然后活动速率总体增加。
视网膜光照停止会产生持续190至700毫秒的单位活动兴奋性后抑制。有人认为这种效应是由光“关闭”激活的视网膜传入神经对瞳孔收缩神经元施加抑制性影响产生的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8328/1396085/7d335d027952/jphysiol01041-0250-a.jpg