Micieli G, Tassorelli C, Martignoni E, Pacchetti C, Bruggi P, Magri M, Nappi G
Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.
Clin Auton Res. 1991 Mar;1(1):55-8. doi: 10.1007/BF01826058.
Different varieties of pupillary abnormalities have been described in Parkinson's disease but it is not clear if this is due to the disease itself or to the pharmacological treatment. In this study, pupil reactivity to various stimuli (dark/light adaptation, light reflex, near vision reaction and electrical sural stimulation) was investigated in 23 de novo parkinsonian patients (not on drugs) to assess pupillary abnormalities and investigate their pathophysiological mechanisms. Parkinsonian patients exhibited larger pupil diameter after light adaptation, as well as a reduced amplitude of contraction and a prolonged contraction time at light reflex. The data obtained confirmed the existence in Parkinson's disease of a pupillary imbalance mainly involving the parasympathetic system.
帕金森病中已描述了不同类型的瞳孔异常，但尚不清楚这是由于疾病本身还是药物治疗所致。在本研究中，对23例初发帕金森病患者（未用药）的瞳孔对各种刺激（暗/光适应、光反射、近视力反应和腓肠神经电刺激）的反应性进行了研究，以评估瞳孔异常并探究其病理生理机制。帕金森病患者在光适应后瞳孔直径更大，并且在光反射时收缩幅度减小、收缩时间延长。所获得的数据证实帕金森病中存在主要涉及副交感神经系统的瞳孔失衡。
