α-[7-甲基-9-甲氧基-5-氧代-呋喃并-[3,2-g][1]-苯并吡喃氧基-4]-丁酸和戊酸及其氨基酯的合成
Synthesis of alpha-[7-methyl-9-methoxy-5-oxo-furo-[3,2-g] [1]-benzopyranoxy-4]-butyric and valeric acids and their aminoesters.
作者信息
Zawadowski T, Kossakowski J, Południkiewicz W, Wiercińska-Radzio C, Uliasz A
出版信息
Pol J Pharmacol Pharm. 1979 Nov-Dec;31(6):633-6.
PMID:550119
Abstract
In the reaction of 4-desmethylkhelline with ethyl alpha-bromobutyrate or alpha-bromovalerate we obtained alpha-[7-methyl-9-methoxy-5-oxo-furo[3,2-g] [1] benzopyranoxy-4]-butyric 2 and valeric 3 acids and later their dialkylaminoethylesters as hydrochlorides (2b--2, 3b--3e). Compounds 2c, 2e, 2f (Table 1) and 3e (Table 2) show a weak hypotensic activity. Moreover compound 2f possesses an antriarrhythmic activity.
摘要
在4-去甲基茵芋碱与α-溴丁酸乙酯或α-溴戊酸的反应中，我们得到了α-[7-甲基-9-甲氧基-5-氧代-呋喃并[3,2-g][1]苯并吡喃氧基-4]-丁酸2和戊酸3，随后得到了它们的盐酸二烷基氨基乙酯（2b - 2，3b - 3e）。化合物2c、2e、2f（表1）和3e（表2）显示出微弱的降压活性。此外，化合物2f具有抗心律失常活性。
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