Kaye Z, Zipser R D, Mayeda S, Zia P K, Horton R
Prostaglandins Med. 1979 Feb;2(2):123-31. doi: 10.1016/0161-4630(79)90047-8.
We investigated the relationship between urinary prostaglandin E (PGE) excretion and sodium and water balance. PGE excretion was measured in thirteen healthy male volunteers on the metabolic ward during conditions of high sodium (200 mmols/day) and low sodium diets (40 mmols/day) and during intravenous administration of saline and of dextrose and water, using each subject as his own control. PGE excretion was higher on the high sodium than on the low sodium diet (191 +/- 37 SE versus 98 +/- 41 ng/6h, p less than 0.01). Saline and dextrose and water infusions significantly increased PGE excretion while subjects were on low sodium diets (to 314 +/- 74 and 443 +/- 152 ng/6h, respectively, p less than 0.01). While on high sodium diets the increase in PGE excretion during infusions was not significant. To further evaluate the role of prostaglandin in sodium excretion the study was repeated with simultaneous administration of indomethacin or ibuprofen to inhibit prostaglandin synthesis. Sodium excretion from saline and dextrose and water infusions were unaltered. The data suggest that dietary content of sodium may alter PGE excretion, but that acute changes in PGE excretion during saline administration reflect water balance rather than sodium load.
我们研究了尿前列腺素E（PGE）排泄与钠和水平衡之间的关系。在代谢病房中，以13名健康男性志愿者为研究对象，分别在高钠饮食（200 mmol/天）、低钠饮食（40 mmol/天）条件下，以及静脉输注生理盐水、葡萄糖和水的过程中，测量PGE排泄量，每个受试者均作为自身对照。高钠饮食时的PGE排泄量高于低钠饮食（分别为191±37 SE对98±41 ng/6小时，p<0.01）。在低钠饮食时，输注生理盐水和葡萄糖及水显著增加了PGE排泄量（分别增至314±74和443±152 ng/6小时，p<0.01）。而在高钠饮食时，输注过程中PGE排泄量的增加并不显著。为进一步评估前列腺素在钠排泄中的作用，研究重复进行，同时给予吲哚美辛或布洛芬以抑制前列腺素合成。输注生理盐水、葡萄糖和水时的钠排泄量未改变。数据表明，饮食中的钠含量可能改变PGE排泄，但输注生理盐水期间PGE排泄的急性变化反映的是水平衡而非钠负荷。
