在大鼠血管制剂中，孕酮会干扰前列腺素（PG）E1的作用，但不会干扰PGE2或PGF2α的作用。
Progesterone interferes with the actions of prostaglandin (PG) E1 but not those of PGE2 or PGF2 alpha in a rat vascular preparation.
作者信息
Oka M, Horrobin D F, Manku M S
出版信息
Prostaglandins Med. 1979 Feb;2(2):161-4. doi: 10.1016/0161-4630(79)90051-x.
In the mammary gland some actions of prolactin seem mediated by PGs. Progesterone blocks several of the mammary effects of prolactin. We therefore investigated the effects of 100 ng/ml progesterone (within the normal human plasma concentration in pregnancy) on the vascular effects of PGE2, PGEF2 alpha and PGE1. Progesterone had no effects on the responses to PGE2 and PGF2 alpha but significantly (p less than 0.01) attenuated the actions of low concentrations of PGE1. It may have enhanced the actions of high PGE1 concentrations. Progesterone appears able to block some effects of PGE1 and to imitate others.
在乳腺中，催乳素的某些作用似乎是由前列腺素介导的。孕酮可阻断催乳素的几种乳腺效应。因此，我们研究了100 ng/ml孕酮（在正常妊娠人血浆浓度范围内）对前列腺素E2、前列腺素F2α和前列腺素E1血管效应的影响。孕酮对前列腺素E2和前列腺素F2α的反应没有影响，但显著（p<0.01）减弱了低浓度前列腺素E1的作用。它可能增强了高浓度前列腺素E1的作用。孕酮似乎能够阻断前列腺素E1的某些作用并模仿其他作用。
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