Gollan F, McDermott J
Resuscitation. 1979;7(3-4):229-36. doi: 10.1016/0300-9572(79)90030-3.
It has been reported that total hypothermic blood exchange holds promise for the treatment of septic shock in animals. Since this procedure does not carry any mortality in out laboratory, we studied its effect in an acute septic shock model. After the intravenous injection of endotoxin (10 mg/kg) and blood transfusions into 33 dogs, severe haemoconcentration, tachypnoea, tachycardia, low cardiac output, metabolic acidosis and hyperpyrexia led uniformly to death within 5 h. All of these symptoms were prevented in five dogs by total hypothermic blood exchange, instituted 5 min after the endotoxin injection. Nevertheless, all of these treated animals died a delayed death. Since the endotoxin particles are rapidly phagocytosed by the reticulo-endothelial system, even very early total blood exchange cannot dislodge them from their intracellular site.
据报道，全身低温血液交换有望用于治疗动物的感染性休克。由于该操作在我们实验室中不会导致任何死亡，我们在急性感染性休克模型中研究了其效果。给33只狗静脉注射内毒素（10毫克/千克）并输血后，严重的血液浓缩、呼吸急促、心动过速、低心输出量、代谢性酸中毒和高热均导致在5小时内死亡。在内毒素注射后5分钟进行的全身低温血液交换使5只狗避免了所有这些症状。然而，所有这些接受治疗的动物都延迟死亡。由于内毒素颗粒会迅速被网状内皮系统吞噬，即使是非常早期的全血交换也无法将它们从细胞内位点清除。
