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致癌物处理器官培养诱导的肺腺瘤。致癌物剂量增加的影响。

Pulmonary adenomata induced by carcinogen treatment in organ culture. Influence of increasing amounts of carcinogen.

作者信息

Davies R F, Major I R, Aberdeen E R

出版信息

Br J Cancer. 1970 Dec;24(4):785-7. doi: 10.1038/bjc.1970.93.

Abstract

Explants of lung from 1 month old inbred BALB/c mice were cultured in vitro for 4 days with 3-methylcholanthrene added to the culture medium at various dose levels. They were subsequently implanted subcutaneously into 6-week-old mice of the same strain.Lung adenomata appeared in a high proportion of explants.

摘要

将1月龄近交系BALB/c小鼠的肺外植体在含有不同剂量水平3-甲基胆蒽的培养基中体外培养4天。随后将它们皮下植入同品系6周龄小鼠体内。高比例的外植体出现了肺腺瘤。

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