Riches A C, Thomas D B
Br J Cancer. 1970 Dec;24(4):833-42. doi: 10.1038/bjc.1970.98.
The growth of a CBA mammary adenocarcinoma has been studied following transplantation to syngeneic and allogeneic recipients, with particular reference to the susceptibilities of the primary and secondary responses elicited by the tumour allografts, to impairment by whole-body X-irradiation and by treatment with rabbit-anti-mouse lymphocyte serum. In syngeneic recipients, the diameter of tumour implants increases linearly with time and there is no difference in the growth curves in females and in males. Later tumour generations grow faster than earlier generations. In allogeneic recipients, there is a relationship between the tumour diameter on day 21 (T) and the dose of X-irradiation (D) administered before implantation:T = 0.028 D - 9.17for early tumour generations (SMT4) but this is obscured for later generations (SMT21). The primary response to tumour allografts was radiosensitive whereas the secondary response was radioresistant. This radioresistance of the secondary response persisted for at least 5 months after primary sensitization. Unlike whole-body X-irradiation, treatment with rabbit-anti-mouse lymphocyte serum suppresses both the primary and secondary responses to tumour allografts. The possibility is considered that after exposure to antigenic stimulation, an immunologically reactive cell population is formed which is radioresistant but sensitive to ALS, unlike the precursor cells from which this population is derived, which are radiosensitive and sensitive to ALS.
在将CBA乳腺腺癌移植到同基因和异基因受体后，对其生长进行了研究，特别关注肿瘤同种异体移植引发的初次和二次反应对全身X射线照射及兔抗小鼠淋巴细胞血清治疗损伤的敏感性。在同基因受体中，肿瘤植入物的直径随时间呈线性增加，雌性和雄性的生长曲线没有差异。后期肿瘤代比早期肿瘤代生长得更快。在异基因受体中，植入前给予的X射线照射剂量（D）与移植后第21天的肿瘤直径（T）之间存在关系：对于早期肿瘤代（SMT4），T = 0.028D - 9.17，但对于后期肿瘤代（SMT21），这种关系不明显。对肿瘤同种异体移植的初次反应对辐射敏感，而二次反应对辐射有抗性。初次致敏后，二次反应的这种辐射抗性至少持续5个月。与全身X射线照射不同，兔抗小鼠淋巴细胞血清治疗会抑制对肿瘤同种异体移植的初次和二次反应。研究认为，在接触抗原刺激后，会形成一个免疫反应性细胞群体，该群体对辐射有抗性但对抗淋巴细胞血清敏感，这与该群体所源自的前体细胞不同，前体细胞对辐射敏感且对抗淋巴细胞血清敏感。
