Nouza K, Nêmec M, Viklický V, Novotný J
Folia Biol (Praha). 1976;22(2):74-81.
Changes in the properties of non-H-2 imcompatible skin allografts, resulting from treating the graft donors with whole-body irradiation, antilymphocyte serum, cyclophosphamide, hydrocortisone, amethopterin and azathioprine, affected differently their survival in the recipients pretreated with normal and antilymphocyte serum. While in NS--pretreated recipients the modified grafts showed the tendency for a prolonged survival, in ALS-pretreated recipients they survived for a shorter time than normal allografts. In ALS-pretreated recipients, also allografts from radiation chimaeras, whose blood-forming system was of the recipient's genotype, survived worse than normal allografts and grafts from the donor syngeneic radiation chimaeras. The findings indicate that a normal physiological state of the graft is necessary for the induction and working of the protective components of the allotrasplantation reaction involved in the graft survival promoting effect of ALS. The significance of passenger leucocytes and of the functional properties of the graft, especially of the reparation cellular and extracellular processes is discussed.
用全身照射、抗淋巴细胞血清、环磷酰胺、氢化可的松、氨甲蝶呤和硫唑嘌呤处理移植物供体，会导致非H - 2不相容皮肤同种异体移植物的特性发生变化，这对其在经正常血清和抗淋巴细胞血清预处理的受体中的存活产生了不同影响。在用正常血清预处理的受体中，经过修饰的移植物显示出存活期延长的趋势，而在用抗淋巴细胞血清预处理的受体中，它们的存活时间比正常同种异体移植物短。在用抗淋巴细胞血清预处理的受体中，来自辐射嵌合体（其造血系统为受体基因型）的同种异体移植物的存活情况也比正常同种异体移植物以及来自供体同基因辐射嵌合体的移植物差。这些发现表明，移植物的正常生理状态对于诱导和发挥参与抗淋巴细胞血清促进移植物存活作用的同种移植反应保护成分是必要的。文中讨论了过客白细胞的意义以及移植物的功能特性，特别是修复细胞和细胞外过程的功能特性。
