关于C3H小鼠对浆细胞瘤5563的大鼠免疫反应的研究。
Studies of the rat immune response to plasmacytoma 5563 in C3H mice.
作者信息
Fakhri O, Hobbs J R
出版信息
Br J Cancer. 1970 Dec;24(4):853-60. doi: 10.1038/bjc.1970.101.
Abstract
Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.
摘要
来自免疫大鼠的洗涤淋巴细胞在体内或体外对小鼠浆细胞瘤5563均无反应。已证明来自免疫大鼠的无细胞淋巴液在体外对肿瘤细胞具有细胞毒性。我们已表明，在经葡聚糖凝胶G - 200分离后，这种效应仅存在于19s组分中。在移植后不久给予这种19s组分时，它能为荷瘤小鼠提供部分保护，但对晚期已形成的肿瘤影响可忽略不计。
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