Joubert J R, de Klerk H C, Malan C
S Afr Med J. 1979 Oct 6;56(15):599-602.
Infestation of humans with the parasite Ascaris lumbricoides may induce high total serum IgE levels, but the influence of this immunogenic response on allergic asthma has not been defined. In this study, the specific antiparasitic IgE-mediated response as determined by skin-prick testing was related to the incidence of allergic asthma in Ascaris-infested patients. A limited number--17% of the non-allergic controls and 51% of the allergic asthmatics--had a clinically detectable immunogenic response to the parasite. The predicted incidence of asthma was significantly higher than the observed incidence in the subjects in whom the Ascaris skin test was positive. This was not found in subjects in whom the Ascaris skin test was negative. Inhalation of Ascaris antigen induced asthmatic reactions in 7 of 8 patients who were Ascaris-positive on skin testing, but not in the negative controls. The groups of patients who respond immunogenically to parasite infestation need to be defined, as they may be predisposed to allergic diseases such as asthma.
人体感染寄生虫蛔虫可能会导致血清总IgE水平升高，但这种免疫原性反应对过敏性哮喘的影响尚未明确。在本研究中，通过皮肤点刺试验测定的特异性抗寄生虫IgE介导反应与蛔虫感染患者的过敏性哮喘发病率相关。少数人——17%的非过敏性对照者和51%的过敏性哮喘患者——对该寄生虫有临床可检测到的免疫原性反应。在蛔虫皮肤试验呈阳性的受试者中，哮喘的预测发病率显著高于观察到的发病率。在蛔虫皮肤试验呈阴性的受试者中未发现这种情况。对8名皮肤试验蛔虫呈阳性的患者中的7名进行蛔虫抗原吸入激发试验，可诱发哮喘反应，但阴性对照者无此反应。需要明确对寄生虫感染产生免疫原性反应的患者群体，因为他们可能易患哮喘等过敏性疾病。
