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A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia.一种用于区分镰状细胞性状和镰状细胞贫血的快速全血溶解度试验。
J Clin Pathol. 1970 Dec;23(9):781-3. doi: 10.1136/jcp.23.9.781.
2
An automated screening technique for the detection of sickle-cell haemoglobin.一种用于检测镰状细胞血红蛋白的自动筛查技术。
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An anthropometric and hematological comparison of sickle cell disease children from rural and urban areas.城乡地区镰状细胞病儿童的人体测量与血液学比较
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Detecting sickle haemoglobin.检测镰状血红蛋白。
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9
An improved solubility test for haemoglobin S.血红蛋白S的一种改良溶解度试验。
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10
Detecting sickle hemoglobin.检测镰状血红蛋白。
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本文引用的文献

1
The ferrohemoglobin solubility test; its accuracy and precision together with values found in the presence of some abnormal hemoglobins.
Clin Chem. 1958 Apr;4(2):145-9.
2
Solubilities of naturally occurring mixtures of human hemoglobin.人血红蛋白天然混合物的溶解度。
Arch Biochem Biophys. 1953 Nov;47(1):148-59. doi: 10.1016/0003-9861(53)90444-5.
3
Sickling tests. Pitfalls in performance and interpretation.镰状试验。操作与解读中的陷阱。
JAMA. 1967 Oct 30;202(5):419-21. doi: 10.1001/jama.202.5.419.
4
A new solubility test for rapid detection of hemoglobin S.一种用于快速检测血红蛋白S的新溶解度试验。
J Indiana State Med Assoc. 1968 Dec;61(12):1651-2.
5
Relatively benign sickle-cell anaemia in 60 patients aged over 30 in the West Indies.西印度群岛60名30岁以上患者的相对良性镰状细胞贫血症。
Br Med J. 1968 Jul 13;3(5610):86-91. doi: 10.1136/bmj.3.5610.86.

一种用于区分镰状细胞性状和镰状细胞贫血的快速全血溶解度试验。

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia.

作者信息

Huntsman R G, Barclay G P, Canning D M, Yawson G I

出版信息

J Clin Pathol. 1970 Dec;23(9):781-3. doi: 10.1136/jcp.23.9.781.

DOI:10.1136/jcp.23.9.781
PMID:5504372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476897/
Abstract

A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0.1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.

摘要

本文描述了一种简单快速的筛查试验，可区分镰状细胞性状和镰状细胞贫血。该试验使用0.1毫升全血，基于还原型镰状血红蛋白的低溶解度。在胎儿血红蛋白含量高的镰状细胞贫血特殊病例中，会得到介于镰状细胞性状和镰状细胞贫血之间的结果。文中讨论了用血液学和电泳技术补充结果的必要性。