De Antoni A, Baccichetti F, Costa C, Vanzan S, Allegri G
Boll Soc Ital Biol Sper. 1979 Sep 15;55(17):1707-13.
Tryptophan metabolism "via kynurenine" after load of amino-acid has been studied in urine of rats before and after induction of experimental light-conditioned dermatitis with psoralen. Tryptophan load in animals during the acute phase of dermatitis (one day after induction) causes a markedly increased urinary excretion of total metabolites in comparison with that obtained before dermatitis. After six days of dermatitis, when the skin damage was in repair, the excretory values after tryptophan load in rats are only slightly increased indicating that the metabolic disturbance is correlated with the skin damage.
在用补骨脂素诱发实验性光化性皮炎前后，对大鼠尿液中氨基酸负荷后“经由犬尿氨酸”的色氨酸代谢进行了研究。在皮炎急性期（诱导后一天），动物体内的色氨酸负荷导致总代谢产物的尿排泄量与皮炎前相比显著增加。皮炎六天后，当皮肤损伤处于修复阶段时，大鼠色氨酸负荷后的排泄值仅略有增加，这表明代谢紊乱与皮肤损伤相关。
