Jeanmougin M, Beaudry P, Garnier J P, Dreux C, Civatte J
Sem Hop. 1984 Mar 29;60(14):967-72.
Disturbances in the kynurenine pathway are present in pellagra and pellagroid syndromes. In 88 photodermatoses, the authors found increased urinary excretion of xanthurenic acid after oral load of tryptophan in a number of light-induced eruptions, i.e. benign summer photodermatosis (40%), polymorphous light eruptions (37%), and persistent light reactions (36%) as well as in patients with acute alcoholic intoxication. These biochemical abnormalities in the kynurenine pathway allow for a pathogenetic approach in some photodermatoses.
糙皮病和糙皮病样综合征存在犬尿氨酸途径紊乱。在88例光皮肤病患者中，作者发现，在一些光诱导性皮疹（即良性夏季光皮肤病，40%；多形性光疹，37%；持续性光反应，36%）以及急性酒精中毒患者中，口服色氨酸负荷后尿中黄尿酸排泄增加。犬尿氨酸途径中的这些生化异常为某些光皮肤病的发病机制研究提供了途径。
