Scarda A, D'Erasmo E, Malaguti Aliberti L, Mancini D, Mazzuoli G F
Boll Soc Ital Biol Sper. 1979 Apr 15;55(7):647-53.
Aim of the present study was to establish the limits and difficulties prevailing in RIA of PTH due to different specificity of antisera. Studies were carried out on normal volunteers and 36 patients with primary hyperparathyroidism (HPT) employing two different assay techniques a) 211/32 antiserum from Wellcome Lab. and b) Immuno Nuclear Corporation Kit. Plasma iPTH values were higher in most primary HPT patients than in normal subjects with both techniques. It is possible nevertheless to differentiate the primary HPT patients with normal plasma iPTH values from normal subjects by correlating plasma iPTH values with corresponding serum calcium values.
本研究的目的是确定由于抗血清特异性不同，在甲状旁腺激素放射免疫分析中普遍存在的局限性和困难。对正常志愿者和36例原发性甲状旁腺功能亢进症（HPT）患者进行了研究，采用两种不同的检测技术：a）来自惠康实验室的211/32抗血清，b）免疫核公司试剂盒。两种技术检测时，大多数原发性HPT患者的血浆完整甲状旁腺激素（iPTH）值均高于正常受试者。然而，通过将血浆iPTH值与相应的血清钙值相关联，有可能将血浆iPTH值正常的原发性HPT患者与正常受试者区分开来。
