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通过放射自显影术研究十烃季铵在大鼠肌肉中的进入情况。

Entry of decamethonium in rat muscle studied by autoradiography.

作者信息

Creese R, Maclagan J

出版信息

J Physiol. 1970 Sep;210(2):363-86. doi: 10.1113/jphysiol.1970.sp009215.

DOI:10.1113/jphysiol.1970.sp009215
PMID:5509874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1395562/
Abstract
  1. When a steady plasma level of decamethonium was maintained by infusion in rats, the labelled compound became concentrated in the region of the end-plate of skeletal muscle, as shown by scintillation counting.2. The distribution of tritium-labelled decamethonium in single muscle fibres was studied by autoradiography of frozen sections, with resolution less than 1 mu.3. After intravenous injection of a dose of decamethonium which produced partial paralysis it was shown that the labelled compound had entered muscle fibres in the region of the end-plate, and for several hundred microns on either side of the end-plate.4. Entry of decamethonium could be demonstrated as early as 30 sec after intra-arterial injection. There was no evidence of any redistribution of labelled drug for a period of 2 hr after the initial entry.5. Previous administration of tubocurarine markedly reduced the entry of labelled decamethonium.
摘要

  1. 当通过向大鼠输注维持十烃季铵的稳定血浆水平时，如闪烁计数所示，标记化合物在骨骼肌终板区域浓缩。

  2. 通过分辨率小于1微米的冷冻切片放射自显影研究了氚标记的十烃季铵在单根肌纤维中的分布。

  3. 静脉注射一剂导致部分麻痹的十烃季铵后，显示标记化合物已进入终板区域的肌纤维，并进入终板两侧数百微米处的肌纤维。

  4. 动脉内注射后最早30秒即可证明十烃季铵进入。在最初进入后的2小时内没有标记药物重新分布的证据。

  5. 先前给予筒箭毒碱显著减少了标记的十烃季铵的进入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/99219e00ecfa/jphysiol01044-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/5746a5cc3460/jphysiol01044-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/c07545847e22/jphysiol01044-0134-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/761964bf295e/jphysiol01044-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/ea925f36f405/jphysiol01044-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/7db35cd2a2e7/jphysiol01044-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/8d753ca01d64/jphysiol01044-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/c33ea72477fe/jphysiol01044-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/99219e00ecfa/jphysiol01044-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/5746a5cc3460/jphysiol01044-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/c07545847e22/jphysiol01044-0134-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/761964bf295e/jphysiol01044-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/ea925f36f405/jphysiol01044-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/7db35cd2a2e7/jphysiol01044-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/8d753ca01d64/jphysiol01044-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/c33ea72477fe/jphysiol01044-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668b/1395562/99219e00ecfa/jphysiol01044-0133-a.jpg

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本文引用的文献

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The pharmacological actions of polymethylene bistrimethyl-ammonium salts.聚亚甲基双三甲基铵盐的药理作用。
Br J Pharmacol Chemother. 1949 Dec;4(4):381-400. doi: 10.1111/j.1476-5381.1949.tb00565.x.
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Depolarization of the motor end-plate by decamethonium and acetylcholine.十烃季铵和乙酰胆碱对运动终板的去极化作用。
J Physiol. 1951 Sep;115(1):41-73. doi: 10.1113/jphysiol.1951.sp004652.
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Some theoretical aspects of radioautography.放射自显影术的一些理论方面。
十烃季铵在去极化肌肉中的作用及筒箭毒碱的影响。
J Physiol. 1970 Sep;210(2):345-61. doi: 10.1113/jphysiol.1970.sp009214.
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Structure and physiology of denervated and re-innervated cockroach muscle.去神经支配和重新神经支配的蟑螂肌肉的结构与生理学
J Physiol. 1973 Apr;230(1):1P-2P.
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Agmatine acts as an antagonist of neuronal nicotinic receptors.胍丁胺作为神经元烟碱受体的拮抗剂。
Br J Pharmacol. 1990 Jan;99(1):207-11. doi: 10.1111/j.1476-5381.1990.tb14680.x.
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Decamethonium in the perfused and immersed rat diaphragm.十烃季铵对灌注和浸泡的大鼠膈肌的作用
Br J Pharmacol. 1975 Jul;54(3):367-74. doi: 10.1111/j.1476-5381.1975.tb07577.x.
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Labelled decamethonium in cat muscle.猫肌肉中标记的十烃季铵。
Br J Pharmacol. 1976 Sep;58(1):141-8. doi: 10.1111/j.1476-5381.1976.tb07703.x.
8
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J Physiol. 1979 Aug;293:247-84. doi: 10.1113/jphysiol.1979.sp012888.
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Proc Soc Exp Biol Med. 1951 Jun;77(2):225-9. doi: 10.3181/00379727-77-18731.
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THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.豚鼠肠道平滑肌对阿托品及相关药物的摄取与乙酰胆碱受体的关系
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