标记的十烃季铵在大鼠肌肉纤维中的移动。
Movement of labelled decamethonium in muscle fibres of the rat.
作者信息
Case R, Creese R, Dixon W J, Massey F J, Taylor D B
出版信息
J Physiol. 1977 Nov;272(2):283-94. doi: 10.1113/jphysiol.1977.sp012044.
Abstract
- Tritium-labelled decamethonium accumulated in diaphragm muscles of the rat in vitro with a peak at the end-plate region and the distributions were fitted by Gaussian curves. 2. Prolonged wash in physiological saline (10 hr) produced some loss in radioactivity but no detectable spread of the labelled compound along the fibres, which indicated that the decamethonium was not in a mobile form. 3. Rats injected with labelled decamethonium showed radioactivity in the diaphragm muscles after 21 days. 4. A slow spread of the labelled compound along the fibres was detected, and from the widening of the Gaussian curves the apparent diffusion coefficient was 1.2 X 10(-8) cm2sec-1, which is less than 1/500 of that in free solution.
摘要
- 氚标记的十烃季铵在体外大鼠膈肌中蓄积，终板区域出现峰值，其分布符合高斯曲线。2. 在生理盐水中长时间冲洗（10小时）导致放射性有一定损失，但未检测到标记化合物沿纤维扩散，这表明十烃季铵不是可移动形式。3. 注射了标记十烃季铵的大鼠在21天后膈肌中显示出放射性。4. 检测到标记化合物沿纤维缓慢扩散，根据高斯曲线变宽情况，表观扩散系数为1.2×10⁻⁸平方厘米每秒，这小于其在自由溶液中扩散系数的1/500。
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2
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J Physiol. 1964 Jun;171(3):504-13. doi: 10.1113/jphysiol.1964.sp007393.
3
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J Pharmacol Exp Ther. 1963 Jan;139:8-17.
4
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