Povýsil C, Matĕjovský Z
Pathol Res Pract. 1979 Dec;166(1):80-9. doi: 10.1016/S0344-0338(79)80009-6.
Electron microscopic examination of three chondroblastomas showed two main cell types, namely pale and dark cells. Multilobulate nuclei characteristic of typical neoplastic chondroblasts were found in both the cell types. Besides differences in cytoplasmic and nuclear density, the cells also differed in nuclear shape and in proportions of various cytoplasmic organelles. Small pale cells resembled prechondroblasts of embryonic cartilage. Large pale cells showed features of chondroblasts. From pale cells of the above type, smooth transitions were observed to the dark cells, possessing dense, less regularly shaped nuclei and typically a larger amount of rough endoplasmic reticulum. Some of the dark cells may represent cells undergoing regressive alterations, but the majority of them seem to represent chondroblasts with imperfect maturation towards chondrocytes. Such findings suggest that benign chondroblastoma is composed of cartilaginous cells with various degrees of differentiation. The finding of occasional cilia is reported.
对三个软骨母细胞瘤进行的电子显微镜检查显示出两种主要细胞类型，即浅色细胞和深色细胞。在这两种细胞类型中均发现了典型肿瘤性软骨母细胞特有的多叶核。除了细胞质和细胞核密度不同外，细胞在核形状以及各种细胞质细胞器的比例方面也存在差异。小的浅色细胞类似于胚胎软骨的前软骨母细胞。大的浅色细胞表现出软骨母细胞的特征。从上述类型的浅色细胞中，观察到向深色细胞的平滑过渡，深色细胞具有致密、形状不太规则的细胞核，通常还有大量粗面内质网。一些深色细胞可能代表正在经历退行性改变的细胞，但其中大多数似乎代表向软骨细胞成熟不完全的软骨母细胞。这些发现表明，良性软骨母细胞瘤由具有不同分化程度的软骨细胞组成。报告了偶尔出现纤毛的情况。
