Nicolescu P G, Eskenasy A
Morphol Embryol (Bucur). 1984 Jul-Sep;30(3):211-6.
The electronmicroscopic investigation of five lung tumors histodiagnosed as macrocellular carcinomas showed the ultrastructural monomorphism of large, variedly shaped neoplastic cells, lack of intercellular junctions, voluminous nuclei with many indentations of nuclear membrane, dispersed euchromatin, large and multiple nucleoli, and nuclear bodies. A reduced number of cytoplasmic organelles was characteristic for these cells, represented mainly by mitochondria, rare rough endoplasmic reticulum, free ribosomes rare Golgi vesicles and flattened tubules, and a various amount of tonofilaments. These features characterized the poorly differentiated proliferation forming these tumors. The elements of differential diagnosis from other poorly differentiated lung tumors (epidermoid and cylindrocubic) are discussed, allowing the consideration of this proliferation type with repressed differentiation and maturation as a real one in the framework of lung carcinomas.
对五例组织学诊断为大细胞癌的肺肿瘤进行的电子显微镜研究显示，大的、形状各异的肿瘤细胞具有超微结构单形性，缺乏细胞间连接，细胞核体积大，核膜有许多凹陷，常染色质分散，有大而多个核仁及核体。这些细胞的特征是细胞质细胞器数量减少，主要由线粒体、罕见的粗面内质网、游离核糖体、罕见的高尔基体小泡和平扁小管以及不同数量的张力丝组成。这些特征表明形成这些肿瘤的是低分化增殖。文中讨论了与其他低分化肺肿瘤（表皮样癌和圆柱立方细胞癌）的鉴别诊断要点，从而可以将这种分化和成熟受抑制的增殖类型视为肺癌范畴内一种真实存在的类型。
