Erenberg A
Early Hum Dev. 1978 Sep;2(3):283-9. doi: 10.1016/0378-3782(78)90031-2.
Cord blood thyroxine (T4) concentrations were measured in 4,068 infants from 28 wk gestation to term. Each chart was reviewed for the following factors: delivery by cesarean section, prolonged rupture of membranes, neonatal asphyxia, meconium-stained amniotic fluid, maternal diabetes mellitus and twinning. Each neonate was evaluated for the Idiopathic Respiratory Distress Syndrome, and low (SGA) or high (LGA) birthweight for gestational age. Within each gestational age group, the mean cord T4 value was similar except for a significantly lower mean cord T4 concentration for the term SGA subgroup. Thus, inclusion of the infant with a complicated neonatal course or the infant born to a high-risk mother in mass screening programs for congenital hypothyroidism using cord serum will not increase the number of false-positive T4 values.
对4068例孕28周直至足月的婴儿测定了脐血甲状腺素（T4）浓度。对每份病历检查了以下因素：剖宫产、胎膜早破、新生儿窒息、羊水胎粪污染、母亲糖尿病和双胎妊娠。对每个新生儿评估特发性呼吸窘迫综合征以及根据胎龄的低出生体重（SGA）或高出生体重（LGA）情况。在每个胎龄组内，除足月SGA亚组的平均脐血T4浓度显著较低外，平均脐血T4值相似。因此，在使用脐血血清进行先天性甲状腺功能减退症的大规模筛查项目中，纳入有复杂新生儿病程的婴儿或高危母亲所生的婴儿，不会增加T4值假阳性的数量。
