脐血甲状腺素和促甲状腺激素水平与胎龄及出生体重的关系。
Relation of cord blood thyroxine and thyrotropin levels to gestational age and birth weight.
作者信息
Prato F S, Reese L, Tevaarwerk G J, Mackenzie R, Hurst C J
出版信息
Can Med Assoc J. 1980 Nov 22;123(10):1007-13.
A program of screening cord blood for evidence of primary neonatal hypothyroidism was implemented in a general hospital. In 13 months 3456 newborns were screened: the thyroxine (T4) and triiodothyronine (T3) concentrations were measured in cord blood samples, and when the T4 level was below 8.0 micrograms/dl thyrotropin was also assayed in the sample. The two-tier program was effective. One hypothyroid newborn was detected and treated. More boys than girls had T4 levels below 8.0 micrograms/dl (9.7% v. 4.7%). The T4 level correlated with birth weight slightly better in the boys (r = 0.28 v. 0.21), and in the boys this correlation was stronger when the birth weight was lower. Regression analysis of the data for 54 sets of twins indicated that the T4 level was more strongly related to gestational age than to birth weight.
一家综合医院实施了一项对脐带血进行筛查以寻找原发性新生儿甲状腺功能减退症证据的项目。在13个月内对3456名新生儿进行了筛查：测量了脐带血样本中的甲状腺素（T4）和三碘甲状腺原氨酸（T3）浓度，当T4水平低于8.0微克/分升时，还对样本进行促甲状腺激素检测。这个两级项目是有效的。检测并治疗了一名甲状腺功能减退的新生儿。T4水平低于8.0微克/分升的男孩比女孩更多（9.7%对4.7%）。男孩的T4水平与出生体重的相关性略强（r = 0.28对0.21），并且在男孩中，当出生体重较低时这种相关性更强。对54对双胞胎的数据进行回归分析表明，T4水平与胎龄的关系比与出生体重的关系更密切。
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