花生四烯酸和二高-γ-亚麻酸生成前列腺素及相关物质的差异调节。I. 乙醇的作用。
Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol.
作者信息
Manku M S, Oka M, Horrobin D F
出版信息
Prostaglandins Med. 1979 Aug;3(2):119-28. doi: 10.1016/0161-4630(79)90079-x.
Ethanol, over the concentration range 33 to 300 mg/100 ml (7.2-65.2 x 10-3 M) caused a dose dependent and highly significant enhancement of conversion of 14C-dihomogammalinolenic acid (DGLA) to prostaglandin (PG) El and to thromboxane (Tx) B1 by human platelets. Ethanol had no significant effect on conversion of 14C-arachidonic acid to PGE2 and TxB2. This concentration range is the one involved in human alcoholic intoxication. The effect could be related to enhanced transport of DGLA to the active site of the cyclo-oxygenase enzyme complex, to a modification of the enzyme complex which changes the way it metabolizes DGLA but not arachidonic acid or to two different enzymes. Whatever the mechanism it seems that it is possible to regulate selectively the formation of 1 and 2 series PGs probably at the cyclo-oxygenase level. The physiological and clinical implications of this are discussed.
乙醇浓度在33至300毫克/100毫升（7.2 - 65.2×10⁻³摩尔/升）范围内，可使人体血小板将¹⁴C - 二高γ-亚麻酸（DGLA）转化为前列腺素（PG）E1和血栓素（Tx）B1的过程呈现剂量依赖性且显著增强。乙醇对¹⁴C - 花生四烯酸转化为PGE2和TxB2没有显著影响。该浓度范围与人体酒精中毒有关。这种作用可能与DGLA向环氧化酶复合物活性位点的转运增强、酶复合物的修饰有关，这种修饰改变了其代谢DGLA的方式，但不影响花生四烯酸的代谢，或者与两种不同的酶有关。无论其机制如何，似乎有可能在环氧化酶水平上选择性地调节1系列和2系列PG的形成。本文讨论了其生理和临床意义。
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