一种新型血栓素类似物在致死性创伤性休克中的保护作用。
Protective effects of a novel thromboxane analog in lethal traumatic shock.
作者信息
Lefer A M, Araki H, Smith J B, Nicolaou K C, Magolda R L
出版信息
Prostaglandins Med. 1979 Sep;3(3):139-46. doi: 10.1016/0161-4630(79)90097-1.
PMID:552102
Abstract
Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole . kg-1 . h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.
摘要
蒎烷血栓素A2（PTA2）是血栓素A2的类似物，可抑制血栓素的形成并拮抗其生物学作用。以1.0微摩尔·千克⁻¹·小时⁻¹的输注速率给药时，PTA2可延长创伤性休克大鼠的存活时间。PTA2还可防止循环血液中血栓素B2、溶酶体蛋白酶组织蛋白酶D和心脏毒性肽心肌抑制因子的蓄积。
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